Practical Laboratory Tools for Monitoring of BCR-ABL1 Transcripts and Tyrosine Kinase (TK) Domain Mutations in Chronic Myeloid Leukemia Patients Undergoing TK Inhibitor Therapy: A Single-Center Experience in Thailand

Objective: CML genetic characteristic known as the appearance of t (9; 22) (q34.1; q11.2) (BCR-ABL1), which is present in more than 95% of cases. Here, we demonstrate a practical laboratory tool for monitoring the BCR-ABL1 transcripts in patients with chronic myeloid leukemia who underwent TK inhibitor therapy.

Methods: Real-time quantitative PCR and direct sequencing to monitor BCR-ABL1 transcripts in 245 treated CML.
Results: At 3 months after the first time point monitoring, we found that 89% (218/245), 2% (5/245), and 9% (22/245) of patients were identified as optimal, warning, and failure response, each. Responses to the workers who declined slightly in the following months 6 optimal 73% (180/245), 18% warning (43/245), and a 9% response failures (22/245). In addition, in response to TKI gradually declined in 12 after the first time point following monitoring optimal 65% (160/245), 13% warning (31/245), and the failure of 22% (54/245). We could detect 20% (49/245) of patients were positive for BCR-ABL1 mutation TKD.

Interestingly, one-third (17 of 49) of TKD mutation positive cases for compounds / polyclonal mutation patterns. While major molecular response was observed in most patients without TKD mutation, resistant to TKI detected in patients with the T315I mutation (n = 9;% average IS = 8.1510, median% IS = 9.7000), compound / polyclonal mutation with T315I (n = 9;% average IS = 13.0779,% median IS = 5.404), and more TKD mutations (n ​​= 14;% average IS = 8.1416, median% IS = 1.060), respectively.

Conlusion: The practical laboratory techniques provide a more comprehensive understanding of the development of CML during drug treatment and may be useful in the previous prognosis. Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease in more than 20% of the general population worldwide. Some combination of factors of non-invasive and scoring models investigated as an indicator of NAFLD. This study aims to validate and adapt score fatty liver was established, which allows identification of NAFLD based on clinical and laboratory data routinely available.

Xcellerate Investigator Portal: Web-Based New Tool for Online Delivery Data Center Laboratory, reports and communications to Clinical Site

Covance Drug Development produces more than 55 million test lab services through its central, requires delivery of more than 10 million reports each year to researchers at 35,000 locations in 89 countries. Historically, most of this data is sent via fax or electronic data transfer in a delimited text or SAS transport file format.

Here, we present a new web portal that allows secure online delivery of lab results, reports, manuals, and training materials, and enables collaboration with research sites through alerts, announcements, and communication. By utilizing the three-tier architecture consisting of a pre-existing data warehouse coupled with application-specific relational database to store configuration data and materialized views for performance optimization, application programming interfaces web quiet (API), and an application-page browser based on user access, offers the very system capabilities and enhanced user experience without requiring changes to the underlying acquisition system and store data.

Recombinant Hydra vulgaris Hydralysin (Hln)

MBS1393758-002mgEColi MyBiosource 0.02mg(E-Coli) 755 EUR

Recombinant Hydra vulgaris Hydralysin (Hln)

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Recombinant Hydra vulgaris Hydralysin (Hln)

MBS1393758-01mgEColi MyBiosource 0.1mg(E-Coli) 905 EUR

Recombinant Hydra vulgaris Hydralysin (Hln)

MBS1393758-01mgYeast MyBiosource 0.1mg(Yeast) 1070 EUR

Recombinant Hydra vulgaris Pedin

MBS1149522-005mgBaculovirus MyBiosource 0.05mg(Baculovirus) 875 EUR

Recombinant Hydra vulgaris Pedin

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Recombinant Hydra vulgaris Pedin

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Recombinant Hydra vulgaris Pedin

MBS1149522-02mgEColi MyBiosource 0.2mg(E-Coli) 640 EUR

Recombinant Hydra vulgaris Pedin

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Recombinant Hydra vulgaris Pedibin

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Recombinant Hydra vulgaris Pedibin

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Recombinant Hydra vulgaris Pedibin

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Recombinant Hydra vulgaris Pedibin

MBS1148200-05mgEColi MyBiosource 0.5mg(E-Coli) 700 EUR

Recombinant Hydra vulgaris Antistasin

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Recombinant Hydra vulgaris Antistasin

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Recombinant Hydra vulgaris Antistasin

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Recombinant Hydra vulgaris Antistasin

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Recombinant Hydra vulgaris Endoglycoceramidase

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Recombinant Hydra vulgaris Endoglycoceramidase

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Recombinant Hydra vulgaris Endoglycoceramidase

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Recombinant Hydra vulgaris Endoglycoceramidase

MBS1353485-02mgEColi MyBiosource 0.2mg(E-Coli) 1390 EUR

Recombinant Hydra vulgaris Endoglycoceramidase

MBS1353485-02mgYeast MyBiosource 0.2mg(Yeast) 1515 EUR

Recombinant Hydra vulgaris Periculin-1

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Recombinant Hydra vulgaris Periculin-1

MBS1388691-002mgEColi MyBiosource 0.02mg(E-Coli) 650 EUR

Recombinant Hydra vulgaris Periculin-1

MBS1388691-002mgYeast MyBiosource 0.02mg(Yeast) 815 EUR

Recombinant Hydra vulgaris Periculin-1

MBS1388691-01mgEColi MyBiosource 0.1mg(E-Coli) 750 EUR

Recombinant Hydra vulgaris Periculin-1

MBS1388691-01mgYeast MyBiosource 0.1mg(Yeast) 955 EUR

Recombinant Hydra viridissima Hydralysin-1 (Hln-1)

MBS1447651-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1125 EUR

Recombinant Hydra viridissima Hydralysin-1 (Hln-1)

MBS1447651-002mgEColi MyBiosource 0.02mg(E-Coli) 755 EUR

Recombinant Hydra viridissima Hydralysin-1 (Hln-1)

MBS1447651-002mgYeast MyBiosource 0.02mg(Yeast) 915 EUR

Recombinant Hydra viridissima Hydralysin-1 (Hln-1)

MBS1447651-01mgEColi MyBiosource 0.1mg(E-Coli) 905 EUR

Recombinant Hydra viridissima Hydralysin-1 (Hln-1)

MBS1447651-01mgYeast MyBiosource 0.1mg(Yeast) 1070 EUR

Recombinant Hydra viridissima Hydralysin-2 (Hln-2)

MBS1450847-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1125 EUR

Recombinant Hydra viridissima Hydralysin-2 (Hln-2)

MBS1450847-002mgEColi MyBiosource 0.02mg(E-Coli) 755 EUR

Recombinant Hydra viridissima Hydralysin-2 (Hln-2)

MBS1450847-002mgYeast MyBiosource 0.02mg(Yeast) 915 EUR

Recombinant Hydra viridissima Hydralysin-2 (Hln-2)

MBS1450847-01mgEColi MyBiosource 0.1mg(E-Coli) 905 EUR

Recombinant Hydra viridissima Hydralysin-2 (Hln-2)

MBS1450847-01mgYeast MyBiosource 0.1mg(Yeast) 1070 EUR

Recombinant Hydra viridissima Hydralysin-3 (Hln-3)

MBS1383547-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1135 EUR

Recombinant Hydra viridissima Hydralysin-3 (Hln-3)

MBS1383547-002mgEColi MyBiosource 0.02mg(E-Coli) 720 EUR

Recombinant Hydra viridissima Hydralysin-3 (Hln-3)

MBS1383547-002mgYeast MyBiosource 0.02mg(Yeast) 890 EUR

Recombinant Hydra viridissima Hydralysin-3 (Hln-3)

MBS1383547-01mgEColi MyBiosource 0.1mg(E-Coli) 865 EUR

Recombinant Hydra viridissima Hydralysin-3 (Hln-3)

MBS1383547-01mgYeast MyBiosource 0.1mg(Yeast) 1040 EUR

Recombinant Hydra vulgaris Morphogenetic neuropeptide

MBS1011399-005mgBaculovirus MyBiosource 0.05mg(Baculovirus) 875 EUR

Recombinant Hydra vulgaris Morphogenetic neuropeptide

MBS1011399-005mgEColi MyBiosource 0.05mg(E-Coli) 490 EUR

Recombinant Hydra vulgaris Morphogenetic neuropeptide

MBS1011399-005mgYeast MyBiosource 0.05mg(Yeast) 690 EUR

Recombinant Hydra vulgaris Morphogenetic neuropeptide

MBS1011399-02mgEColi MyBiosource 0.2mg(E-Coli) 640 EUR

Recombinant Hydra vulgaris Morphogenetic neuropeptide

MBS1011399-05mgEColi MyBiosource 0.5mg(E-Coli) 695 EUR

Hydra-Sponge w/ Peptone Water - PK100

FSA1172 Scientific Laboratory Supplies PK100 244.35 EUR

Anti Hydra SP5 mouse monoclonal antibody

MBS157902-01mL MyBiosource 0.1mL 350 EUR

Anti Hydra SP5 mouse monoclonal antibody

MBS157902-5x01mL MyBiosource 5x0.1mL 1250 EUR

Recombinant Hydra vulgaris KS1 protein (KS1)

MBS1066916-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1120 EUR

Recombinant Hydra vulgaris KS1 protein (KS1)

MBS1066916-002mgEColi MyBiosource 0.02mg(E-Coli) 700 EUR

Recombinant Hydra vulgaris KS1 protein (KS1)

MBS1066916-002mgYeast MyBiosource 0.02mg(Yeast) 875 EUR

Recombinant Hydra vulgaris KS1 protein (KS1)

MBS1066916-01mgEColi MyBiosource 0.1mg(E-Coli) 840 EUR

Recombinant Hydra vulgaris KS1 protein (KS1)

MBS1066916-01mgYeast MyBiosource 0.1mg(Yeast) 1020 EUR

Recombinant Hydra vulgaris Annexin-B12 (ANXB12)

MBS1096630-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1195 EUR

Recombinant Hydra vulgaris Annexin-B12 (ANXB12)

MBS1096630-002mgEColi MyBiosource 0.02mg(E-Coli) 845 EUR

Recombinant Hydra vulgaris Annexin-B12 (ANXB12)

MBS1096630-002mgYeast MyBiosource 0.02mg(Yeast) 985 EUR

Recombinant Hydra vulgaris Annexin-B12 (ANXB12)

MBS1096630-01mgEColi MyBiosource 0.1mg(E-Coli) 1015 EUR

Recombinant Hydra vulgaris Annexin-B12 (ANXB12)

MBS1096630-01mgYeast MyBiosource 0.1mg(Yeast) 1120 EUR

Recombinant Hydra vulgaris Tropomyosin-1 (TROP1)

MBS1144651-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1135 EUR

Recombinant Hydra vulgaris Tropomyosin-1 (TROP1)

MBS1144651-002mgEColi MyBiosource 0.02mg(E-Coli) 765 EUR

Recombinant Hydra vulgaris Tropomyosin-1 (TROP1)

MBS1144651-002mgYeast MyBiosource 0.02mg(Yeast) 925 EUR

Recombinant Hydra vulgaris Tropomyosin-1 (TROP1)

MBS1144651-01mgEColi MyBiosource 0.1mg(E-Coli) 920 EUR

Recombinant Hydra vulgaris Tropomyosin-1 (TROP1)

MBS1144651-01mgYeast MyBiosource 0.1mg(Yeast) 1080 EUR

Recombinant Hydra vulgaris Actin, non-muscle 6.2

MBS1128576-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1250 EUR

Recombinant Hydra vulgaris Actin, non-muscle 6.2

MBS1128576-002mgEColi MyBiosource 0.02mg(E-Coli) 915 EUR

Recombinant Hydra vulgaris Actin, non-muscle 6.2

MBS1128576-002mgYeast MyBiosource 0.02mg(Yeast) 1040 EUR

Recombinant Hydra vulgaris Actin, non-muscle 6.2

MBS1128576-01mgEColi MyBiosource 0.1mg(E-Coli) 1100 EUR

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MBS1128576-01mgYeast MyBiosource 0.1mg(Yeast) 1185 EUR

Recombinant Hydra vulgaris Laminin subunit beta-1

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MBS1355494-002mgEColi MyBiosource 0.02mg(E-Coli) 650 EUR

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MBS1355494-01mgEColi MyBiosource 0.1mg(E-Coli) 755 EUR

Recombinant Hydra vulgaris Laminin subunit beta-1

MBS1355494-01mgYeast MyBiosource 0.1mg(Yeast) 955 EUR

Recombinant Hydra viridissima 40S ribosomal protein SA

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Recombinant Hydra viridissima 40S ribosomal protein SA

MBS1043552-002mgEColi MyBiosource 0.02mg(E-Coli) 815 EUR

Recombinant Hydra viridissima 40S ribosomal protein SA

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Recombinant Hydra viridissima 40S ribosomal protein SA

MBS1043552-01mgYeast MyBiosource 0.1mg(Yeast) 1125 EUR

Recombinant Hydra vulgaris Elongation factor 1-alpha

MBS1050397-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1335 EUR

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MBS1050397-002mgEColi MyBiosource 0.02mg(E-Coli) 1030 EUR

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Recombinant Hydra vulgaris Elongation factor 1-alpha

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Recombinant Hydra vulgaris Elongation factor 1-alpha

MBS1050397-01mgYeast MyBiosource 0.1mg(Yeast) 1285 EUR

Recombinant Hydra attenuata SP5 protein, N- His Tag

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Recombinant Hydra attenuata SP5 protein, N- His Tag

MBS157545-01mg MyBiosource 0.1mg 410 EUR

Recombinant Hydra attenuata SP5 protein, N- His Tag

MBS157545-5x01mg MyBiosource 5x0.1mg 1520 EUR

Recombinant Hydra viridissima Putative ascorbate peroxidase (APX1)

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Recombinant Hydra viridissima Putative ascorbate peroxidase (APX1)

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Recombinant Hydra viridissima Putative ascorbate peroxidase (APX1)

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Recombinant Hydra viridissima Putative ascorbate peroxidase (APX1)

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Recombinant Hydra viridissima Putative ascorbate peroxidase (APX1)

MBS1299441-01mgYeast MyBiosource 0.1mg(Yeast) 1160 EUR

Recombinant Hydra vulgaris Ras-like protein RAS1 (RAS1)

MBS1188614-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1110 EUR

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MBS1188614-002mgYeast MyBiosource 0.02mg(Yeast) 865 EUR

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MBS1188614-01mgEColi MyBiosource 0.1mg(E-Coli) 830 EUR

Recombinant Hydra vulgaris Ras-like protein RAS1 (RAS1)

MBS1188614-01mgYeast MyBiosource 0.1mg(Yeast) 1010 EUR

Recombinant Hydra vulgaris Ras-like protein RAS2 (RAS2)

MBS1150542-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1110 EUR

Recombinant Hydra vulgaris Ras-like protein RAS2 (RAS2)

MBS1150542-002mgEColi MyBiosource 0.02mg(E-Coli) 705 EUR

Recombinant Hydra vulgaris Ras-like protein RAS2 (RAS2)

MBS1150542-002mgYeast MyBiosource 0.02mg(Yeast) 860 EUR

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MBS1150542-01mgEColi MyBiosource 0.1mg(E-Coli) 825 EUR

Recombinant Hydra vulgaris Ras-like protein RAS2 (RAS2)

MBS1150542-01mgYeast MyBiosource 0.1mg(Yeast) 1010 EUR

Recombinant Hydra vulgaris 60S ribosomal protein L15 (RPL15)

MBS1148433-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1125 EUR

Recombinant Hydra vulgaris 60S ribosomal protein L15 (RPL15)

MBS1148433-002mgEColi MyBiosource 0.02mg(E-Coli) 705 EUR

Recombinant Hydra vulgaris 60S ribosomal protein L15 (RPL15)

MBS1148433-002mgYeast MyBiosource 0.02mg(Yeast) 875 EUR

Recombinant Hydra vulgaris 60S ribosomal protein L15 (RPL15)

MBS1148433-01mgEColi MyBiosource 0.1mg(E-Coli) 845 EUR

Recombinant Hydra vulgaris 60S ribosomal protein L15 (RPL15)

MBS1148433-01mgYeast MyBiosource 0.1mg(Yeast) 1025 EUR

Recombinant Hydra vulgaris G2/mitotic-specific cyclin-B

MBS1068728-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1235 EUR

Recombinant Hydra vulgaris G2/mitotic-specific cyclin-B

MBS1068728-002mgEColi MyBiosource 0.02mg(E-Coli) 900 EUR

Recombinant Hydra vulgaris G2/mitotic-specific cyclin-B

MBS1068728-002mgYeast MyBiosource 0.02mg(Yeast) 1025 EUR

Recombinant Hydra vulgaris G2/mitotic-specific cyclin-B

MBS1068728-01mgEColi MyBiosource 0.1mg(E-Coli) 1080 EUR

Recombinant Hydra vulgaris G2/mitotic-specific cyclin-B

MBS1068728-01mgYeast MyBiosource 0.1mg(Yeast) 1170 EUR

Recombinant Hydra viridissima G2/mitotic-specific cyclin-A

MBS1123045-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1290 EUR

Recombinant Hydra viridissima G2/mitotic-specific cyclin-A

MBS1123045-002mgEColi MyBiosource 0.02mg(E-Coli) 970 EUR

Recombinant Hydra viridissima G2/mitotic-specific cyclin-A

MBS1123045-002mgYeast MyBiosource 0.02mg(Yeast) 1085 EUR

Recombinant Hydra viridissima G2/mitotic-specific cyclin-A

MBS1123045-01mgEColi MyBiosource 0.1mg(E-Coli) 1130 EUR

Recombinant Hydra viridissima G2/mitotic-specific cyclin-A

MBS1123045-01mgYeast MyBiosource 0.1mg(Yeast) 1230 EUR

Recombinant Hydra viridissima G2/mitotic-specific cyclin-B

MBS1261963-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1265 EUR

Recombinant Hydra viridissima G2/mitotic-specific cyclin-B

MBS1261963-002mgEColi MyBiosource 0.02mg(E-Coli) 935 EUR

Recombinant Hydra viridissima G2/mitotic-specific cyclin-B

MBS1261963-002mgYeast MyBiosource 0.02mg(Yeast) 1055 EUR

Recombinant Hydra viridissima G2/mitotic-specific cyclin-B

MBS1261963-01mgEColi MyBiosource 0.1mg(E-Coli) 1125 EUR

Recombinant Hydra viridissima G2/mitotic-specific cyclin-B

MBS1261963-01mgYeast MyBiosource 0.1mg(Yeast) 1200 EUR

Recombinant Hydra viridissima Adenylyl cyclase-associated protein (CAP)

MBS1030165-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1345 EUR

Recombinant Hydra viridissima Adenylyl cyclase-associated protein (CAP)

MBS1030165-002mgEColi MyBiosource 0.02mg(E-Coli) 1045 EUR

Recombinant Hydra viridissima Adenylyl cyclase-associated protein (CAP)

MBS1030165-002mgYeast MyBiosource 0.02mg(Yeast) 1140 EUR

Recombinant Hydra viridissima Adenylyl cyclase-associated protein (CAP)

MBS1030165-01mgEColi MyBiosource 0.1mg(E-Coli) 1220 EUR

Recombinant Hydra viridissima Adenylyl cyclase-associated protein (CAP)

MBS1030165-01mgYeast MyBiosource 0.1mg(Yeast) 1300 EUR

Recombinant Hydra oligactis Heat shock 70 kDa protein (HSP70)

MBS1203402-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1035 EUR

Recombinant Hydra oligactis Heat shock 70 kDa protein (HSP70)

MBS1203402-002mgEColi MyBiosource 0.02mg(E-Coli) 610 EUR

Recombinant Hydra oligactis Heat shock 70 kDa protein (HSP70)

MBS1203402-002mgYeast MyBiosource 0.02mg(Yeast) 785 EUR

Recombinant Hydra oligactis Heat shock 70 kDa protein (HSP70)

MBS1203402-01mgEColi MyBiosource 0.1mg(E-Coli) 710 EUR

Recombinant Hydra oligactis Heat shock 70 kDa protein (HSP70)

MBS1203402-01mgYeast MyBiosource 0.1mg(Yeast) 920 EUR

Recombinant Hydra vulgaris Myosin heavy chain, clone 203, partial

MBS1040747-INQUIRE MyBiosource INQUIRE Ask for price

Recombinant Hydra vulgaris Translationally-controlled tumor protein homolog

MBS1366985-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1105 EUR

Recombinant Hydra vulgaris Translationally-controlled tumor protein homolog

MBS1366985-002mgEColi MyBiosource 0.02mg(E-Coli) 695 EUR

Recombinant Hydra vulgaris Translationally-controlled tumor protein homolog

MBS1366985-002mgYeast MyBiosource 0.02mg(Yeast) 855 EUR

Recombinant Hydra vulgaris Translationally-controlled tumor protein homolog

MBS1366985-01mgEColi MyBiosource 0.1mg(E-Coli) 815 EUR

Recombinant Hydra vulgaris Translationally-controlled tumor protein homolog

MBS1366985-01mgYeast MyBiosource 0.1mg(Yeast) 1005 EUR

Recombinant Hydra vulgaris PC3-like endoprotease variant B, partial

MBS1168588-INQUIRE MyBiosource INQUIRE Ask for price

Recombinant Hydra vulgaris Tyrosine-protein kinase STK (STK), partial

MBS1066436-INQUIRE MyBiosource INQUIRE Ask for price

Recombinant Hydra vulgaris PC3-like endoprotease variant A, partial

MBS1238977-INQUIRE MyBiosource INQUIRE Ask for price

Recombinant Hydra vulgaris Tyrosine-protein kinase HTK16 (HTK16), partial

MBS1250981-INQUIRE MyBiosource INQUIRE Ask for price

Recombinant Hydra vulgaris Fibroblast growth factor receptor (FGFR), partial

MBS1335630-005mgBaculovirus MyBiosource 0.05mg(Baculovirus) 1255 EUR

Recombinant Hydra vulgaris Fibroblast growth factor receptor (FGFR), partial

MBS1335630-005mgMammalianCell MyBiosource 0.05mg(Mammalian-Cell) 1510 EUR

Recombinant Hydra vulgaris Fibroblast growth factor receptor (FGFR), partial

MBS1335630-05mgEColi MyBiosource 0.5mg(E-Coli) 1255 EUR

Recombinant Hydra vulgaris Fibroblast growth factor receptor (FGFR), partial

MBS1335630-05mgYeast MyBiosource 0.5mg(Yeast) 1510 EUR

Recombinant Hydra vulgaris Fibroblast growth factor receptor (FGFR), partial

MBS1335630-1mgEColi MyBiosource 1mg(E-Coli) 1990 EUR

Recombinant Hydra vulgaris Putative insulin-like peptide receptor (HTK7), partial

MBS1441399-INQUIRE MyBiosource INQUIRE Ask for price

Recombinant Hydra vulgaris Cyclic AMP-responsive element-binding protein (CREB)

MBS1085322-002mgBaculovirus MyBiosource 0.02mg(Baculovirus) 1135 EUR

Recombinant Hydra vulgaris Cyclic AMP-responsive element-binding protein (CREB)

MBS1085322-002mgEColi MyBiosource 0.02mg(E-Coli) 720 EUR

Recombinant Hydra vulgaris Cyclic AMP-responsive element-binding protein (CREB)

MBS1085322-002mgYeast MyBiosource 0.02mg(Yeast) 890 EUR

Recombinant Hydra vulgaris Cyclic AMP-responsive element-binding protein (CREB)

MBS1085322-01mgEColi MyBiosource 0.1mg(E-Coli) 865 EUR

After 3 months with a controlled release of the 6500 in the early-adopter sites, which Xcellerate Investigator Portal deployed to all 240,000 of Covance Central Laboratory Services existing users, gaining widespread acceptance and pointed to significant benefits in productivity, comfort, and user experience.

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