Practical Laboratory Tools for Monitoring of BCR-ABL1 Transcripts and Tyrosine Kinase (TK) Domain Mutations in Chronic Myeloid Leukemia Patients Undergoing TK Inhibitor Therapy: A Single-Center Experience in Thailand

Practical Laboratory Tools for Monitoring of BCR-ABL1 Transcripts and Tyrosine Kinase (TK) Domain Mutations in Chronic Myeloid Leukemia Patients Undergoing TK Inhibitor Therapy: A Single-Center Experience in Thailand

Objective: CML genetic characteristic known as the appearance of t (9; 22) (q34.1; q11.2) (BCR-ABL1), which is present in more than 95% of cases. Here, we demonstrate a practical laboratory tool for monitoring the BCR-ABL1 transcripts in patients with chronic myeloid leukemia who underwent TK inhibitor therapy. Methods: Real-time quantitative PCR and direct sequencing to … Czytaj dalej